What is the NIH Stroke Scale?
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The National Institutes of Health Stroke Scale (NIHSS) is a 15-item bedside examination that measures the neurological deficit caused by a stroke. Each item is scored from 0 (normal) upward and the items are added for a total of 0 to 42. Brott and colleagues at the University of Cincinnati first published it in Stroke in 1989 for use in acute stroke trials. The version used today, with each limb scored separately, is the NINDS form adopted for the NINDS t-PA trial, and it is now the standard severity score in stroke care and research.
How is the NIHSS scored?
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Go through the items in order: level of consciousness (1a), two questions (1b), two commands (1c), gaze, visual fields, facial palsy, motor function of each arm and each leg, limb ataxia, sensation, language, dysarthria, and extinction and inattention. Score what the patient does on the first attempt without coaching, then add the points. Items that cannot be tested because of an amputation, joint fusion or intubation are recorded as UN and add no points.
What NIHSS score is a severe stroke?
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A grouping used in many studies is 0 for no deficit on the scale, 1 to 4 minor stroke, 5 to 15 moderate stroke, 16 to 20 moderate to severe stroke and 21 to 42 severe stroke. These bands are a convention, not part of the original scale, and a low score can still mean a disabling deficit such as aphasia or hemianopia.
Does the NIHSS predict outcome?
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Yes, as a group average. In 1,281 patients from the TOAST trial, each additional point lowered the chance of an excellent outcome by 24% at 7 days and 17% at 3 months; 46% of patients with scores of 7 to 10 and 23% with scores of 11 to 15 had an excellent outcome at 3 months. The authors concluded that a score of 16 or more forecasts a high probability of death or severe disability, and 6 or less a good recovery (Adams 1999).
What NIHSS score suggests a large vessel occlusion?
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Higher scores make an occlusion more likely, but there is no safe cut-off. In 2,152 patients with vessel imaging, a score of 9 or more within 3 hours of onset had a positive predictive value of 86.4% for an occlusion in the anterior circulation, and 7 or more between 3 and 6 hours 84.4%. Only 5% of patients with a central occlusion seen within 3 hours scored below 4. In the posterior circulation and after 6 hours, the score predicted occlusion poorly (Heldner 2013).
Does an NIHSS of 0 rule out stroke?
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No. In a series of 20 patients with an infarct on diffusion-weighted MRI and an NIHSS of 0, the usual symptoms were headache, vertigo and nausea, the infarct was often in the posterior circulation, and truncal ataxia was the most common sign (Martin-Schild 2011). The scale does not test gait, truncal ataxia or swallowing.
How do you score an intubated or comatose patient?
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For an intubated patient, item 1b scores 1 if they cannot speak for a reason other than aphasia, item 9 is tested by writing, and dysarthria (item 10) is recorded as UN. When item 1a is 3 (unresponsive), the instructions give 2 for sensory loss (item 8) and 3 for language (item 9), and ataxia (item 7) is absent because the patient cannot understand the task.
Does the NIHSS treat left and right hemisphere strokes equally?
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Not quite. Seven of the 42 points relate to language and only two to neglect, so right hemisphere strokes score lower for the same size of infarct. In the NINDS t-PA trial, the median infarct volume of right hemisphere strokes was about double that of left hemisphere strokes in each 5-point band below 20 (Woo 1999).
How reliable is the NIHSS between examiners?
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Reliability is good for most items when examiners are trained. In the original 1989 version of the scale the mean interrater kappa was 0.69 (Brott 1989). After video training of 162 investigators, most items had moderate to excellent agreement, but facial palsy and ataxia had poor agreement (kappa below 0.40) (Lyden 1994). This video training became the basis of NIHSS certification.
Is this the same as the modified NIHSS?
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No. This calculator scores the full 15-item NIHSS. Shortened versions, such as the modified NIHSS, leave out some items and give lower totals, so the two should not be mixed in one record or compared directly.