Asfar P et al., N Engl J Med 2014
In 776 patients with septic shock, targeting a MAP of 80 to 85 mm Hg instead of 65 to 70 mm Hg did not change mortality at 28 days (36.6% vs 34.0%) or 90 days. New atrial fibrillation was more common with the higher target. In the chronic hypertension subgroup, the higher target reduced renal replacement therapy, without a difference in mortality.
N Engl J Med: Journal Metrics Score 29.8, Q1 · cited 1,263 times